Preparation method for vinblastine



The invention discloses a preparation method for vinblastine. The method comprises the following steps of: making dehydrated vinblastine serving as a starting raw material react with a hydride in an aqueous solution of oxygen-containing ferric trichloride (FeCl3.6H2O) and ammonium oxalate; and performing technological processes such as column-layer separation, salification and the like on the obtained product to obtain vinblastine sulfate, wherein the purity is more than or equal to 60 percent (HPLC (High Performance Liquid Chromatography)), and the yield (W/W) is about 45 percent. The method has a simple process, reasonable cost and high industrial application value; and a novel measure for producing a vinblastine raw material is provided.




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Cited By (1)

    Publication numberPublication dateAssigneeTitle
    CN-104892642-ASeptember 09, 2015广州白云山汉方现代药业有限公司Method for purifying vindesine