Preparation method for vinblastine

一种长春碱的制备方法

Abstract

本发明公开了一种长春碱的制备方法,包括:以脱水长春碱为起始原料,在含氧的三氯化铁(FeCl3·6H2O)和草酸铵的水溶液中与氢化物反应,所得产物经柱层分离、成盐等工艺过程制得长春碱硫酸盐,纯度≥60%(HPLC),收率(W/W)约45%。该方法工艺简单、成本合理,为长春碱原料的生产提供了一种新的途径,具有很好的产业化应用价值。
The invention discloses a preparation method for vinblastine. The method comprises the following steps of: making dehydrated vinblastine serving as a starting raw material react with a hydride in an aqueous solution of oxygen-containing ferric trichloride (FeCl3.6H2O) and ammonium oxalate; and performing technological processes such as column-layer separation, salification and the like on the obtained product to obtain vinblastine sulfate, wherein the purity is more than or equal to 60 percent (HPLC (High Performance Liquid Chromatography)), and the yield (W/W) is about 45 percent. The method has a simple process, reasonable cost and high industrial application value; and a novel measure for producing a vinblastine raw material is provided.

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    Publication numberPublication dateAssigneeTitle
    CN-104892642-ASeptember 09, 2015广州白云山汉方现代药业有限公司Method for purifying vindesine